What is the Descartes-11 Clinical Trial?

This Phase I/II study is evaluating the safety and feasibility of an investigational CAR T-cell therapy called Descartes-11 in eligible patients with active multiple myeloma.

Am I eligible?

You may be eligible if are 18 years and older and have:

  • active multiple myeloma that is relapsed or refractory to therapy;
  • measurable disease;
  • adequate vital organ function; and
  • no active infection.

Patients with prior CAR T-cell therapy, anti-BCMA therapy, and allotransplant are allowed.  Patients with active plasma cell leukemia are not eligible.

Additional eligiblity criteria are available on ClinicalTrials.gov.

What Will Happen?

If you choose to participate and qualify, Descartes-11 will be custom-made for you from your own blood cells. Descartes-11 cells are CAR T-cells, which are T-cells that have been modified to attack myeloma (tumor) cells. To modify the cells, the Sponsor inserts new instructions into the T-cells. These instructions cause the cells to produce a new piece of cellular machinery called a CAR (Chimeric Antigen Receptor).

How will I receive Descartes-11?

Before you can receive Descartes-11 cells, you will receive three days of chemotherapy.

After the chemotherapy, Descartes-11 will be infused into your bloodstream.

Will I be reimbursed for travel and accommodation?

Reimbursement may be provided for some types of travel and accommodation.  Please contact study staff for details.


Center for Cancer and Blood Disorders
Bethesda, MD

Medical College of Wisconsin
Milwaukee, WI

Memorial Healthcare System
Hollywood, FL

Contact us for additional information about the Descartes-11 Clinical Trial

Call Cartesian Clinical Trials at 1-302-648-6497, email us at trials@cartesiantx.com or enter your information below and click the SEND button.


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