Cartesian is the leader in RNA cell therapy, focusing on engineering cells with RNA to overcome the limitations of conventional cell engineering, which uses DNA to modify cells irreversibly. Unfortunately, DNA-modified cells can behave unpredictably in the body; there is the possibility that they may proliferate out of control, cause severe toxicities, and even survive unchecked for months or years. For this reason, conventional cell therapies are most frequently used in very ill patients with the most advanced cancers.
Cartesian uses the RNA Armory® to engineer RNA into cells, making time-controlled changes. Our RNA cell therapies are safer because they have predictable lives within the body. They can treat patients beyond those with the most advanced cancers (e.g., newly-diagnosed cancer patients), as well as conditions beyond oncology (e.g., autoimmune and respiratory disorders).