The Leader in RNA Cell Therapies

Cartesian’s vision is to cure disease by RNA engineering any cell, to deliver to any tissue, any combination of therapies. To realize its vision, Cartesian uses the RNA Armory®, its proprietary cell therapy platform, to engineer combinations of RNA therapies into cells, and targets these cells precisely to the site of disease. The company is currently conducting multiple clinical trials for patients with autoimmune, oncologic and respiratory disorders.

Cartesian operates its wholly-owned, state-of-the-art GMP manufacturing facility in Gaithersburg, MD. Cartesian’s commanding IP position benefits in part from a broad, exclusive patent license from the National Cancer Institute.

Management Team

Cartesian Michael Singer

Executive Advisors

Mr. Ted Henderson, a member of the Board of Directors at Cartesian, has served as a Managing Director at Schooner Capital since 2004. He currently serves as a director at a number of healthcare portfolio companies, including 4G Clinical, Millstone Medical Outsourcing, and SRS Medical. He previously led Schooner’s investment in Mimetogen Pharmaceuticals (sold to Allergan), and served as a director at Topokine Therapeutics (sold to Allergan) and Best Doctors (sold to a private equity firm). Ted is a cum laude graduate of Dartmouth College with an MBA from Harvard Business School.

Dr. LaMattina is a Senior Advisor to Cartesian. As the former Senior Vice President, Pfizer Inc and President, Pfizer Global Research and Development, Dr. LaMattina oversaw the drug discovery and development efforts of over 12,000 colleagues in the United States, Europe and Asia. Dr. LaMattina is a 30 year veteran of Pifzer Inc, having joined as a medicinal chemist in 1977. He is currently a Senior Partner at PureTech Health.

Dr. Niederhuber is a Senior Advisor to Cartesian. As the former Director of the NCI at the National Institutes of Health, Dr. Niederhuber oversaw the cancer research efforts of more than 5,000 NCI employees and managed a budget of over 5 billion dollars. He is currently Executive Vice President and CEO of the Inova Translational Medicine Institute, where he directs highly sophisticated genomic analyses with the goal of delivering excellence in personalized healthcare, research and education. Dr. Niederhuber is an internationally recognized oncologic surgeon who has given over 350 professional presentations, 250 peer-reviewed articles, and edited or co-edited 9 books.

Clinical Advisors

Dr. Anderson is a Senior Advisor to Cartesian and an internationally recognized researcher on multiple myeloma, the focus of his laboratory and clinical research studies over the last three decades. He has developed laboratory and animal models of the tumor in its microenvironment which have allowed for both identification of novel targets and validation of novel targeted therapies, and has then rapidly translated these studies to clinical trials culminating in FDA approval of novel targeted therapies. His paradigm for identifying and validating targets in the tumor cell and its milieu has transformed myeloma therapy and markedly improved patient outcome. He is a recipient of many scientific and humanitarian awards including: the International Myeloma Workshop Waldenstrom’s Award; the International Myeloma Foundation Robert A. Kyle Lifetime Achievement Award; the American Association for Cancer Research Joseph H. Burchenal Award; and the American Cancer Society Medal of Honor in Science. He is a member of the Institute of Medicine of the National Academy of Sciences, served as President of the International Myeloma Society, and is President-elect of the American Society of Hematology. Dr. Anderson is the Kraft Family Professor of Medicine at Harvard Medical School as well as Director of the Jerome Lipper Multiple Myeloma Center and Lebow Institute for Myeloma Therapeutics at Dana-Farber Cancer Institute. He is a Doris Duke Distinguished Clinical Research Scientist and American Cancer Society Clinical Research Professor.

Dr. Landgren is a Senior Advisor to Cartesian. Dr. Landgren is one of the world leaders in the field of early treatment strategies and molecular- and cell-based monitoring of minimal residual disease (MRD) detection in multiple myeloma and its precursor states. He leads a translational research program at Memorial Sloan-Kettering Cancer Center (MSKCC) designed to discover new treatment paradigms integrating modern therapy and novel MRD assays. Dr. Landgren has designed and led the definitive study showing that all multiple myeloma patients are preceded by a precursor stage. As part of his ongoing research program, he is studying molecular mechanisms underlying the trajectory from precursor to full-blown multiple myeloma with the goal to develop treatment strategies aiming to delay, prevent, and ultimately define a cure for multiple myeloma. Dr. Landgren has published over 250 peer-reviewed publications and he is a frequently invited speaker at national and international hematology conferences. He serves on several research committees and editorial boards for scientific journals. Dr. Landgren is Professor of Medicine and Chief Attending Physician of the Myeloma Service at MSKCC.

Ivan Borrello is a Senior Advisor to Cartesian and internationally recognized expert on immunotherapy for multiple myeloma. His group was the first to describe the use of marrow infiltrating lymphocytes (MILs) as a source of highly tumor specific T cells for adoptive T cell therapy. This work has led to several clinical trials in which his group showed the ability of activated MILs to impart measurable tumor specific immunity. His group is also exploring various approaches to enhance the use MILs in a variety of different settings and in diseases other than myeloma. Dr. Borrello is an Associate Professor at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in the divisions of Tumor Immunology and Hematologic Malignancies. He received his MD degree from the Medical College of Virginia. Completed his Residency in Internal Medicine at the University of Chicago and his Fellowship in Oncology at Johns Hopkins where he then has continued as a faculty member. He also serves as the medical director of the Cell Therapy Lab.


Cartesian is expanding its world-class team of scientists dedicated to curing disease through developing cutting-edge cell therapies. Our highly integrated approach is a rare find in biotech; it means that discovery, cGMP manufacturing, and clinical operations all happen under one roof. Team members learn and grow through exposure to an immersive experience. A sense of family stems from close, cross-functional, and continuous conversation with highly committed colleagues. The result is fast-paced innovation, leading to next-generation therapies for our patients.

We are proud members of the fast-growing Gaithersburg biotech community. Please contact us at if you share our passion for developing the next-generation of cell therapies.


704 Quince Orchard Rd
Gaithersburg, MD

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