Pipeline

With multiple clinical and preclinical assets in development, our growing product pipeline is bringing RNA Cell Therapy to autoimmune indications.

Myasthenia gravis

Descartes-08

First RNA Cell Therapy in an autoimmune disease

SLE, other AAAD

Descartes-08

AAAD, myeloma

Descartes-15

AAAD

Descartes-33

Undisclosed

Undisclosed

AAAD: autoantibody-associated autoimmune diseases
SLE: Systemic Lupus Erythematosus
rMSC: Mesenchymal Stem Cells transfected with mRNA
LN: Lymph node

Autoimmune

Myasthenia Gravis

Generalized myasthenia gravis (gMG) is a debilitating autoimmune disease affecting over 60,000 people in the U.S. Treatment of gMG requires the chronic use of toxic immunosuppressants.

DESCARTES-08, Cartesian’s clinical-stage lead product candidate, is the first RNA CAR T-cell (rCAR-T) therapy for autoimmune diseases. DESCARTES-08 contains killer T-cells designed to hunt down pathogenic plasma cells that secrete autoantibodies.

In a Phase 2a study, Descartes-08 was observed to be safe and well-tolerated, and to induce deep and durable responses in patients with gMG.

We are currently enrolling patients with gMG in a Phase 2b randomized controlled trial (RCT).

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